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KMID : 1123920090230040848
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 4 p.848 ~ p.852
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Subacute Oral Toxicity of Taeumjowi-tang in SD Rats
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Yu Tae-Weon
Choi Bong-Jae
Park Soo-Yeon
Chang Mun-Seog
Park Seong-Kyu
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Abstract
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Taeumjowi-tang is originated in Donguisusebowon edited by Lee Je-Ma. The objective of this study was to investigate the subacute toxicity of Taeumjowi-tang in rats. Several doses(0, 125, 250, 500, 1,000, and 2,000 mg/kg) of Taeumjowi-tang were administered to rats for 4 weeks. The mortality, clinical signs, body weights and gross findings were examined for experimental period. No dead animals were found during the experimental period. In addition, any differences were not found between control and treated groups in clinical signs, hematology, serum biochemistry, and other findings. In conclusion, the no observed adverse effect level(NOAEL) for Taeumjowi-tang was over 2,000 mg/kg/day in rats.
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KEYWORD
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Taeumjowi-tang, subacute toxicity, rat, oral administration
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